Thermoplastic composites remain underutilized as primary satellite bus structures, largely due to the absence of integrated design approaches that, simultaneously, account for material anisotropy, manufacturing constraints, and launcher-driven requirements. This work addresses that gap through the development of a modular thermoplastic satellite bus tailored to the structural drivers of very low Earth orbit (VLEO) missions, including mass efficiency, drag-aware geometry, and end-of-life considerations. Carbon-fibre-reinforced polyether-ether-ketone (PEEK-CF) is selected using a multi-criteria VIKOR decision-making method that considers manufacturability, mechanical performance, thermal stability, and environmental resistance. The structural design is developed in alignment with thermoforming and over-moulding processes and emphasizes modularity and scalability. High-fidelity finite element analyses are conducted to assess quasi-static launch loads, modal behaviour, and random vibration environments, using system-level constraints derived from TRL-9 commercial off-the-shelf (COTS) components. The resulting structure, developed to TRL 3-4, corresponds to an 11 kg microsatellite compliant with the load and frequency requirements of a representative rideshare launcher. The study demonstrates the feasibility of a fully thermoplastic satellite bus through an integrated co-design of material, manufacturing, structural, and mission requirements, with applicability to other small satellite classes.